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Roles of Serum Amyloid A 1 Protein Isoforms in Rheumatoid Arthritis Article

Elaine Lai-Han Leung, Huan-Ling Lai, Run-Ze Li, Hu-Dan Pan, Ze-Bo Jiang, Ying Li, Fu-Gang Duan, Jia-Hui Xu, Yi-Zhong Zhang, A-Xi Shi, Chun-Li Wei, Fang-Yuan Zhang, Xiao-Jun Yao, Liang Liu

Engineering 2022, Volume 10, Issue 3,   Pages 174-182 doi: 10.1016/j.eng.2020.08.018

Abstract:

Secondary amyloid A amyloidosis, a lethal complication, is induced when acute or chronic infectioncoexists with over-secretion of the serum amyloid A 1 (SAA1) protein and deposition in key internalHowever, the role of SAA1 in RA pathogenesis and its complications remains unknown.that the arthritis-inducing effect of SAA1.2 transcription in the knee joints and mutant SAA1These findings indicate that SAA1 protein isoforms, particularly SAA1.2, play a significant role in the

Keywords： Serum amyloid A 1     Rheumatoid arthritis     Pathogenetic     Intra-articular    

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of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2,   Pages 283-295 doi: 10.1007/s11705-017-1687-2

Abstract: Amyloid- (A ) protein aggregation is the main hallmark of Alzheimer’s disease (AD).indicate that the peptide cyclization is a promising approach to enhance the performance of peptide-based amyloid

Keywords： Alzheimer’s disease     amyloid β-protein     cyclic peptide     inhibition     protein aggregation    

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: The aggregation of amyloid -protein (A ) is tightly linked to the pathogenesis of Alzheimer’s disease

Keywords： Alzheimer’s disease     amyloid β-protein     peptide inhibitors     protein-protein interaction     molecular    

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Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 293-296 doi: 10.1007/s11684-017-0516-9

Abstract:

Familial amyloid cardiomyopathy is a challenging condition that mimics many other diseases, particularlyGiven these findings, the diagnosis of familial amyloid cardiomyopathy, which was misdiagnosed as chronic

Keywords： transthyretin (TTR) cardiac amyloidosis     sick sinus syndrome     chronic Guillain-Barre syndrome    

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Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 502-508 doi: 10.1007/s11684-017-0590-z

Abstract: virus (HBV) are integrated into the life cycle of HBV replication, and the potential significance of serumThe production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBVTherefore, the concept of virological response is redefined as persistent loss of serum HBV DNA and HBVTherefore, the loss of serum HBV RNA would likely be a promising predicator for safe drug discontinuationThe clinical status of consistent loss of serum HBV RNA accompanied with low serum HBsAg levels might

Keywords： chronic hepatitis B     serum HBV RNA     nucleos(t)ide analogs     virological response     para-functional cure    

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: with chronic renal failure, whether they have had hemodialysis or not, the specificity of some of the serumThe effects of renal function and hemodialysis were examined on serum levels of some of the tumor markersIn group 1, Ccr was ≤25 mL/min. In group 2, Ccr was between 25 and 50 mL/min.There were no significant differences among the three groups in the serum concentrations of CA, AFP,Hemodialysis further increased the serum level of CA and NSE.

Keywords： CKD     non-dialysis     valuable     detection     chronic    

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Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 658-666 doi: 10.1007/s11684-019-0707-7

Abstract: post-treatment follow-up was 99 weeks (12–213); mean age, 57.8 years old; 52%, males; 79%, genotype (GT) 1;presence of cirrhosis ( =0.001), co-existing non-alcoholic steatohepatitis (NASH) ( = 0.035), and GT 1elevation is common in patients with CHC and independently associated with NASH, cirrhosis, and GT 1.

Keywords： chronic hepatitis C     α fetoprotein     direct acting antiviral treatment     cirrhosis    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: Therefore, identifying serum biomarkers that indicate MPP progression and exploring new targeted drugsIn this study, serum samples were collected from patients with general MPP (GMPP) and SMPP to conduct

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein     mechanistic target of rapamycin kinase inhibitor    

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The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 352-355 doi: 10.1007/s11684-007-0067-6

Abstract: The aim of this paper was to investigate the change of serum leptin and its relationship with plateletSerum leptin was detected by enzyme linked immunosorbent assay.Multifactorial stepwise regression analysis showed that serum leptin in CHD patients was independentlyLogistic analysis demonstrated that serum leptin was independently correlated with the risk of CHD (serum leptin could affect blood platelet activation.
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Effect of electrokinetic property of charged polyether sulfone membrane on bovine serum albumin fouling

Xiaorong Meng, Shanshan Huo, Lei Wang, Xudong Wang, Yongtao Lv, Weiting Tang, Rui Miao, Danxi Huang

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0907-9

Abstract: The effects of PES membrane interfacial electrokinetic property on the bovine serum albumin (BSA) membrane

Keywords： Charged PES UF membrane     BSA     Electrokinetic characterization     Adhesion force     Jump distance    

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Trends in serum lipid levels of healthy Chinese in Shanghai from 1973 to 1999

CHEN Haozhu, ZHOU Jun, CHEN Bin, ZHUANG Hanzhong, JIN Xuejuan, HAN Qingqing

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 5-10 doi: 10.1007/s11684-008-0002-5

Abstract: We assessed the secular trends in the serum lipid levels in Shanghai residents from 1973 to 1999.from four independent, cross-sectional, population-based surveys were used to analyze the trends in serumSerum lipid levels were measured in a single laboratory throughout the entire study period.A non-significant increase was noted from 1973–1974 to 1982–1983 in the serum lipid profiles; howeverSimilar trends were observed in the mean serum triglyceride (TG) and the mean serum low-density lipoprotein
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Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 101-105 doi: 10.1007/s11684-011-0111-4

Abstract: The serum TNF-α level was detected using radioactive immunity.The results showed that β-elemene can downregulate the levels of plasma endotoxins, serum TNF-&alpha

Keywords： liver fibrosis     beta-elemene     endotoxin     CD14    

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Mechanism of hepatocellular damage in rat caused by low serum selenium

LU Yi, QU Bo, LIU Chang, YU Liang, Liu Xuemin, WANG Haohua, JIANG An, ZHANG Xiaogang

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 255-258 doi: 10.1007/s11684-008-0048-4

Abstract: The aim of this paper is to investigate the mechanism of hepatocellular damage in rats caused by low serumAt the end of the 12 week, the levels of serum selenium, glutathione peroxidase (GPX) and malondialdehydeThe levels of serum selenium and GPX in group A were markedly lower than those in group B.

Keywords： process     glutathione peroxidase     hepatocellular damage     group     Keshan Disease    

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Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 235-240 doi: 10.1007/s11684-010-0002-0

Abstract: This study was aimed to detect maternal serum levels of thromboxane B2 (TXB2) in different durationsMaternal serum levels of TXB2 were measured by enzyme-linked immunoassay.The pathogenetic condition and pregnancy outcomes of these cases were observed. (1) Among the 180 previouslyHigher levels of maternal serum TXB2 were detected a long time before clinical symptoms appeared.The maternal serum TXB2 after 20 weeks of gestation had predictive value, and the index after 30 weeks

Keywords： thromboxane B2     preeclampsia    

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Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 216-226 doi: 10.1007/s11684-022-0920-7

Abstract: RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC serumWe identified tRF-Gln-TTG-006, which was remarkably upregulated in HCC serum (training cohort: 24 HCCIn summary, our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

Keywords： tsRNA     biomarker     hepatocarcinoma    

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Title Author Date Type Operation

Roles of Serum Amyloid A 1 Protein Isoforms in Rheumatoid Arthritis

Elaine Lai-Han Leung, Huan-Ling Lai, Run-Ze Li, Hu-Dan Pan, Ze-Bo Jiang, Ying Li, Fu-Gang Duan, Jia-Hui Xu, Yi-Zhong Zhang, A-Xi Shi, Chun-Li Wei, Fang-Yuan Zhang, Xiao-Jun Yao, Liang Liu

Journal Article

of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Journal Article

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Journal Article

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum

Journal Article

The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Journal Article

Effect of electrokinetic property of charged polyether sulfone membrane on bovine serum albumin fouling

Xiaorong Meng, Shanshan Huo, Lei Wang, Xudong Wang, Yongtao Lv, Weiting Tang, Rui Miao, Danxi Huang

Journal Article

Trends in serum lipid levels of healthy Chinese in Shanghai from 1973 to 1999

CHEN Haozhu, ZHOU Jun, CHEN Bin, ZHUANG Hanzhong, JIN Xuejuan, HAN Qingqing

Journal Article

Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Journal Article

Mechanism of hepatocellular damage in rat caused by low serum selenium

LU Yi, QU Bo, LIU Chang, YU Liang, Liu Xuemin, WANG Haohua, JIANG An, ZHANG Xiaogang

Journal Article

Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Journal Article

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Journal Article